Strain a Mouse Lung Tumor Bioassay
Identifieur interne : 003721 ( Main/Exploration ); précédent : 003720; suivant : 003722Strain a Mouse Lung Tumor Bioassay
Auteurs : Gary D. Stoner [États-Unis] ; Michael B. Shimkin [États-Unis]Source :
- International Journal of Toxicology [ 1091-5818 ] ; 1982-01.
English descriptors
- Teeft :
- Active compound, Adenoma, Aflatoxin, Alveolar epithelial cells, Anthranilate, Assay, Average number, Bioassay, Bromide, Carbamate, Carcinogen, Carcinogenesis, Carcinogenesis bioassay, Carcinogenic, Carcinogenic activity, Carcinogenic agents, Carcinogenic potency, Carcinogenicity, Chemical carcinogens, Chemical classes, Chronic inhalation, Cinnamyl, Cinnamyl alcohol, Cinnamyl aldehyde, Cinnamyl anthranilate, Compound, Compound strain, Cultured adenoma cells, Dose exposure, Dose levels, Dose lung tumors exposure, Dose lung tumors route, Drinking water, Epithelial cells, Equal activity, False positives, First description, Food additive, Food additives, Hydrazine, Hydrazine sulfate, Life term studies, Liver tumors, Lnst, Lung, Lung adenoma bioassay, Lung adenomas, Lung surface, Lung tumor, Lung tumor induction, Lung tumor production, Lung tumor response, Lung tumors, Lungtumor production, Manganous chloride, Mannitol myleran, Many laboratories, Marginal response, Metal salts, Methyl, Methyl anthranilate, Methyl iodide, Mitotic figures, Molar, Molar dose, Molar dose basis, Mouse, Mouse lung, Mouse lung adenomas, Mouse lung tumor bioassay, Mouse tumorigenicity, Multiple lung tumors, Mutagenic activity, Myleran, Natl, Natl cancer lnst, Neoplastic response, Nitrogen mustards, Nucleotide base analogs, Other compounds, Polycyclic hydrocarbons, Positive carcinogen, Potent inducer, Preliminary toxicology, Pulmonary adenomas, Pulmonary tumor response, Pulmonary tumors, Resistant strains, Schroeder, Several classes, Shimkin, Shimkin table, Significant increase, Silylating agents, Specific lung cell types, Spontaneous lung tumors, Spontaneous tumors, Stoner, Strain mice, Sulfate, Swiss mice, Transplacental carcinogenesis, Tricaprylin, Trimethylsilyl group, Tumor, Tumor response, Tumor values, Untreated, Untreated mice, Uracil, Uracil mustard, Urethan, Vehicle controls, Weisburger.
Abstract
This report summarizes data on the testing of 228 chemicals for carcinogenic activity by the strain A mouse lung adenoma bioassay. The assay is of six months duration and can distinguish two-fold dose differences in carcinogenic potential of compounds from a variety of chemical classes. Most compounds that induced lung tumors in strain A mice have also evoked a neoplastic response in other experimental animal bioassays and/or demonstrated mutagenic activity in various short-term tests. Recommendations are made for future studies on the: (a) distribution and metabolism of chemicals in strain A mouse lung tissue and in specific lung cell types, (b) ability of the lung adenoma bioassay to detect promoting agents, and (c) use of the bioassay to investigate the interactions of more than one chemical.
Url:
DOI: 10.3109/10915818209013138
Affiliations:
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Stoner</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pathology, Medical College of Ohio, Toledo</wicri:cityArea></affiliation></author><author wicri:is="90%"><name sortKey="Shimkin, Michael B" sort="Shimkin, Michael B" uniqKey="Shimkin M" first="Michael B." last="Shimkin">Michael B. Shimkin</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Community Medicine, University of California-San Diego, La Jolla</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">International Journal of Toxicology</title><idno type="ISSN">1091-5818</idno><idno type="eISSN">1092-874X</idno><imprint><publisher>SAGE Publications</publisher><pubPlace>Sage CA: Los Angeles, CA</pubPlace><date type="published" when="1982-01">1982-01</date><biblScope unit="volume">1</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="145">145</biblScope><biblScope unit="page" to="169">169</biblScope></imprint><idno type="ISSN">1091-5818</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1091-5818</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Active compound</term><term>Adenoma</term><term>Aflatoxin</term><term>Alveolar epithelial cells</term><term>Anthranilate</term><term>Assay</term><term>Average number</term><term>Bioassay</term><term>Bromide</term><term>Carbamate</term><term>Carcinogen</term><term>Carcinogenesis</term><term>Carcinogenesis bioassay</term><term>Carcinogenic</term><term>Carcinogenic activity</term><term>Carcinogenic agents</term><term>Carcinogenic potency</term><term>Carcinogenicity</term><term>Chemical carcinogens</term><term>Chemical classes</term><term>Chronic inhalation</term><term>Cinnamyl</term><term>Cinnamyl alcohol</term><term>Cinnamyl aldehyde</term><term>Cinnamyl anthranilate</term><term>Compound</term><term>Compound strain</term><term>Cultured adenoma cells</term><term>Dose exposure</term><term>Dose levels</term><term>Dose lung tumors exposure</term><term>Dose lung tumors route</term><term>Drinking water</term><term>Epithelial cells</term><term>Equal activity</term><term>False positives</term><term>First description</term><term>Food additive</term><term>Food additives</term><term>Hydrazine</term><term>Hydrazine sulfate</term><term>Life term studies</term><term>Liver tumors</term><term>Lnst</term><term>Lung</term><term>Lung adenoma bioassay</term><term>Lung adenomas</term><term>Lung surface</term><term>Lung tumor</term><term>Lung tumor induction</term><term>Lung tumor production</term><term>Lung tumor response</term><term>Lung tumors</term><term>Lungtumor production</term><term>Manganous chloride</term><term>Mannitol myleran</term><term>Many laboratories</term><term>Marginal response</term><term>Metal salts</term><term>Methyl</term><term>Methyl anthranilate</term><term>Methyl iodide</term><term>Mitotic figures</term><term>Molar</term><term>Molar dose</term><term>Molar dose basis</term><term>Mouse</term><term>Mouse lung</term><term>Mouse lung adenomas</term><term>Mouse lung tumor bioassay</term><term>Mouse tumorigenicity</term><term>Multiple lung tumors</term><term>Mutagenic activity</term><term>Myleran</term><term>Natl</term><term>Natl cancer lnst</term><term>Neoplastic response</term><term>Nitrogen mustards</term><term>Nucleotide base analogs</term><term>Other compounds</term><term>Polycyclic hydrocarbons</term><term>Positive carcinogen</term><term>Potent inducer</term><term>Preliminary toxicology</term><term>Pulmonary adenomas</term><term>Pulmonary tumor response</term><term>Pulmonary tumors</term><term>Resistant strains</term><term>Schroeder</term><term>Several classes</term><term>Shimkin</term><term>Shimkin table</term><term>Significant increase</term><term>Silylating agents</term><term>Specific lung cell types</term><term>Spontaneous lung tumors</term><term>Spontaneous tumors</term><term>Stoner</term><term>Strain mice</term><term>Sulfate</term><term>Swiss mice</term><term>Transplacental carcinogenesis</term><term>Tricaprylin</term><term>Trimethylsilyl group</term><term>Tumor</term><term>Tumor response</term><term>Tumor values</term><term>Untreated</term><term>Untreated mice</term><term>Uracil</term><term>Uracil mustard</term><term>Urethan</term><term>Vehicle controls</term><term>Weisburger</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This report summarizes data on the testing of 228 chemicals for carcinogenic activity by the strain A mouse lung adenoma bioassay. The assay is of six months duration and can distinguish two-fold dose differences in carcinogenic potential of compounds from a variety of chemical classes. Most compounds that induced lung tumors in strain A mice have also evoked a neoplastic response in other experimental animal bioassays and/or demonstrated mutagenic activity in various short-term tests. Recommendations are made for future studies on the: (a) distribution and metabolism of chemicals in strain A mouse lung tissue and in specific lung cell types, (b) ability of the lung adenoma bioassay to detect promoting agents, and (c) use of the bioassay to investigate the interactions of more than one chemical.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Ohio</li></region></list><tree><country name="États-Unis"><region name="Ohio"><name sortKey="Stoner, Gary D" sort="Stoner, Gary D" uniqKey="Stoner G" first="Gary D." last="Stoner">Gary D. Stoner</name></region><name sortKey="Shimkin, Michael B" sort="Shimkin, Michael B" uniqKey="Shimkin M" first="Michael B." last="Shimkin">Michael B. Shimkin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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